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Microdosing 101: Potential Benefits, Protocols, and Precautions

Updated: Nov 15, 2023

Microdosing 101: Potential Benefits, Protocols, and Precautions

In recent years, the concept of microdosing – consuming sub-perceptual amounts of psychedelics – has taken the world by storm. Advocates claim it boosts creativity, enhances mood, and sharpens focus. But what's the science behind it, and how does one navigate this space safely? Let's break it down.

What is Microdosing?

Microdosing involves taking roughly 1/10th to 1/20th of a typical recreational dose of a psychedelic substance, such as LSD or psilocybin mushrooms. At these doses, the user generally doesn't experience hallucinations or significant altered states but might notice subtle shifts in perception and cognition.

Potential Benefits

  1. Enhanced Creativity: Many users report an increased flow of ideas and an improved ability to problem-solve.

  2. Improved Mood: Some individuals find microdosing helpful as a mood stabilizer or as a way to combat symptoms of depression.

  3. Increased Focus: Enhanced concentration and absorption in tasks can be another potential benefit.

  4. Reduced Anxiety: Some users claim a reduction in anxiety levels, though this can vary widely among individuals.


While there's no one-size-fits-all approach, here are a few of the popular guides. Find one that works for you.

Dr. James Fadiman's Protocol

  1. Dose Day: Take the microdose in the morning.

  2. Observe: Notice and reflect on any changes in mood, perception, and behavior over the next two days.

  3. Break: Refrain from microdosing for the next two days to prevent tolerance buildup.

  4. Repeat: After the two-day break, you can dose again.

Stamet's Stack

The Stamets Method, also referred to as the "Stamets Stack," is a widely recognized magic mushroom microdosing regimen pioneered by esteemed mycologist Paul Stamets. He championed the combination of psilocybin mushrooms with additional ingredients to amplify and extend the microdosing effects.

This unique blend combines psilocybin mushrooms with Lion's Mane mushrooms, which are cherished for their potential in stress management and cognitive improvement. Additionally, Niacin (vitamin B3) is incorporated, believed to boost the uptake of psilocybin. The Stamet's Method is particularly suited for individuals aiming to bolster cognitive functions.

Every Other Day Protocol

This regimen is best suited for individuals addressing particular mental health challenges, including depression, anxiety disorders, PTSD, ADHD, cluster headaches, and migraines. Given the potent nature of this protocol, it's essential to proceed only under the guidance of a microdosing specialist and to use minimal doses. If you're considering microdosing for mental health purposes, don't venture solo! It's crucial to consult with your physician, a healthcare expert, and a microdosing specialist to guarantee both safety and effectiveness.

The Nightcap Protocol

The Nightcap Protocol is a distinctive microdosing regimen tailored for individuals aiming to harness the potential sleep-enhancing benefits of microdosing. Some users of magic truffles or mushrooms report a mild sensation of tiredness or sleepiness, while others might not discern any effects. This protocol capitalizes on such drowsiness to potentially enhance sleep quality.

The Nightcap Protocol refers to taking a psychedelic microdose every other night just before sleep. This dose, merely a fraction of a regular amount (typically around 0.1 grams), should be consumed a minimum of an hour before bedtime. This timing is thought to allow the psychedelic effects to intertwine with the sleep cycle, possibly fostering deeper, more rejuvenating rest.

Two distinct methodologies define the Nightcap Protocol:

  1. The Microdosing Institute Protocol: Here, practitioners consume the microdose on the first night, rest on the subsequent night, take another dose on the third, and again rest on the fourth. This pattern persists for a duration of four to eight weeks, after which there's a break to ward off tolerance build-up.

  2. The Fadiman Protocol: This approach dictates dosing on the first and fourth nights, with a two-night gap between dosages. Similar to the first method, this cycle continues for four to eight weeks, succeeded by a rest period to prevent tolerance.

Responses to the Nightcap Protocol can vary. Some recount experiencing more vivid dreams and waking up feeling more revitalized after a pre-sleep microdose. Conversely, others might notice interruptions in their sleep or other undesired side effects. Due to these varied reactions, it's imperative to proceed with the Nightcap Protocol with prudence, closely observing personal experiences. Always ensure the protocol is followed under the supervision of a qualified doctor or health professional.

Intuitive Microdosing

Intuitive Microdosing offers a personalized and adaptive method of microdosing, letting users administer doses based on their intuition, ensuring they maintain at least a day's gap between each dose. In contrast to other structured protocols, Intuitive Microdosing doesn't adhere to a fixed timetable or dosage plan. Users are guided to attune to their bodies, administering microdoses when they perceive a need.

This approach is particularly suited for those who have previously undergone one or two cycles of a regimented microdosing procedure and are now well-acquainted with their dosage needs. It empowers individuals to modulate their doses in line with their unique requirements rather than adhering to a pre-defined structure.

However, the flexibility of Intuitive Microdosing necessitates diligent observation of the microdose's effects. It's crucial for users to document their experiences, fine-tuning their doses to optimize therapeutic benefits while sidestepping adverse reactions.

It's crucial to highlight that nearly all microdosing regimens incorporate an "off-cycle" or a resting phase, typically spanning 2-4 weeks. This break is essential for preserving the effectiveness of the treatment and preventing the buildup of tolerance. Additionally, this pause stimulates the brain's innate neurotransmitter production, which likely contributes to the sustained benefits of the method even after one discontinues dosing.


  1. Legality: Always be aware of the legal status of substances in your country or state.

  2. Mental Health: If you have a history of psychosis or certain other mental health disorders, consult a healthcare professional before considering microdosing.

  3. Tolerance: Psychedelics can lead to tolerance, meaning more of the substance is required for the same effects. Following a protocol can help prevent this.

  4. Interactions: If you're on any medications, especially SSRIs or other mood stabilizers, be cautious. There could be interactions, so always consult with a healthcare provider.


Microdosing, with its potential to enhance mood, creativity, and focus, presents a fascinating realm of possibility. However, it's essential to approach it with an informed and cautious mindset. As with any burgeoning field, more research is needed, but the initial results and widespread anecdotal reports are certainly intriguing.

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